MTNR1B, Rabbit anti-Human, Polyclonal, Millipore Sigma™

Catalog No.	Quantity
ABT189025UG	25 μg

Catalog No. ABT189025UG Supplier MilliporeSigma Supplier No. ABT189025UG

Description

Rabbit Polyclonal Antibody

Anti-MTNR1B Antibody, Cat. No. ABT1890, is a rabbit polyclonal antibody that detects MTNR1B and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.

Melatonin receptor type 1B (UniProt: P49286; also known as Mel-1B-R, Mel1b receptor) is encoded by the MTNR1B gene (Gene ID: 4544) in human. Mel-1B-R is a member of the G-protein coupled 1 family that is predominantly expressed in retina and to lesser extent in brain tissue. . Mel-1B-R activity is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Mel-1B-R mediates the reproductive and circadian actions of melatonin. Melatonin is shown to be involved in body mass regulation in mammals and this effect is suggest to be mediated by a direct action of melatonin on Mel-1B receptors on brown adipocytes. Melatonin is reported to act as a chemopreventive agent and its levels inversely correlate with the risk of developing cancer. In this regard melatonin induces p38-dependent phosphorylation of both p53 and histone H2AX. Activation of the p53-dependent DNA damage response by melatonin is mediated by both Mel-1A and Mel-1B receptors. The absence of either receptor impairs melatonin's ability to reduce both cell proliferation and clonogenic potential of cancer cells. A variant in MTNR1B gene is reported to worsen the deleterious effect of melatonin on glucose tolerance in humans. (Ref.: Brydon, L. et al. (2001). Endocrinology. 142(10):4264-4271; Santoro, R., et al. (2013). Carcinogenesis. 34(5):1051-1061).

Specifications

• Antigen: MTNR1B
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected MTNR1B in human retina tissue.
• Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
• Gene Alias: Melatonin receptor type 1B;Mel-1B-R
• Gene Symbols: MTNR1B
• Host Species: Rabbit
• Immunogen: KLH-conjugated linear peptide corresponding to 20 amino acids from the N-terminal region of human Melatonin receptor type 1B.
• Molecular Weight of Antigen: 40.19 kDa calculated.
• Purification Method: Affinity Purified
• Quantity: 25 μg
• Regulatory Status: RUO
• Research Discipline: Cell Structure
• Primary or Secondary: Primary
• Test Specificity: This rabbit polyclonal antibody detects Melatonin receptor type 1B in human.
• Target Species: Human
• Content And Storage: Stable for 1 year at 2-8°C from date of receipt.