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Invitrogen™ MTSS1 Polyclonal Antibody
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Catalog No. PIPA5116535
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PIPA5116535 100 μL
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Catalog No. PIPA5116535 Supplier Invitrogen™ Supplier No. PA5116535
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Description

Rabbit Polyclonal Antibody

Positive Samples: HeLa, HT-29, U-87MG, Mouse liver, Mouse brain, Mouse heart, Rat liver Immunogen sequence: LPAPPDGPEE RGEHSPESPS VGEGPQGVTS MPSSMWSGQA SVNPPLPGPK PSIPEEHRQA IPESEAEDQE REPPSATVSP GQIPESDPAD LSPRDTPQGE D.

Metastasis suppressor protein 1 (MTSS1) [MIM, missing in metastasis], was first discovered as missing transcripts from metastatic bladder and prostate cancer cells. MTSS1 is a 755 amino acid protein, having multidomain and scaffolding function. It has a proline-rich/SH3 binding region and a serine-rich region with EGF or PDGF/Src consensus sites. It contains anactin-binding Wiskott-Aldrich syndrome protein homology-2 motif (WH2) at the C-terminus while the N-terminal IMD domain (IRSp53-MIM domain) interact with membranes and bundle actin filament. The WH2 domain binds to actin monomers and plays an important role in actin cytoskeleton reorganization. Recently, MIM was found to interact with cortactin via SH3 domains. In addition, MTSS1 enhanced cortactin- and Arp2/3-dependent actin polymerization. It is thus involved in cell motility and morphogenesis and also interacts with sonic hedgehog/Gli signaling in epidermal cells. MTSS1 acts as an important regulator of cell growth and development and is known to express in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MTSS1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.88 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene MTSS1
Gene Accession No. O43312, Q8R1S4
Gene Alias 2310003N14Rik; actin monomer-binding protein; BC024131; D130001D01Rik; hypothetical protein; KIAA0429; metastasis suppressor 1; metastasis suppressor protein 1; Metastasis suppressor YGL-1; Mim; MIMA; MIMB; missing in metastasis protein; mKIAA0429; MTSS I-BAR domain containing 1; MTSS1; MTSS1, I-BAR domain containing; Protein MTSS 1; protein MTSS 1; metastasis suppressor protein 1
Gene Symbols MTSS1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 630-730 of human MTSS1 (NP_0555663).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 211401, 362918, 9788
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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