MUC1 Antibody (SPM533), PE, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP234782PE

Catalog No. NBP234782PE

Description

MUC1 Monoclonal specifically detects MUC1 in Human samples. It is validated for Flow Cytometry.

Specifications

• Antigen: MUC-1
• Classification: Monoclonal
• Conjugate: PE
• Gene Alias: Breast carcinoma-associated antigen DF3, Carcinoma-associated mucin, CD227, CD227 antigen, DF3 antigen, EMA, episialin, H23 antigen, H23AG, KL-6, MAM6, MUC-1, MUC1/ZD, mucin 1, cell surface associated, mucin 1, transmembrane, mucin-1, Peanut-reactive urinary mucin, PEMMUC-1/SEC, PEMT, Polymorphic epithelial mucin, PUMMUC-1/X, tumor associated epithelial mucin, Tumor-associated epithelial membrane antigen, Tumor-associated mucin
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: In Western blotting, it recognizes proteins in MW range of 265-400kDa, identified as different glycoforms of EMA. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit and the C-terminal beta subunit. The alpha subunit has cell adhesive properties. It can act both as an adhesion and an anti-adhesion protein. EMA may provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain, which is involved in cell signaling, through phosphorylations and protein-protein interactions. In immunohistochemical assays, it superbly stains routine formalin/paraffin carcinomas. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
• Content And Storage: Store at 4C in the dark.
• Isotype: IgG2a λ

• Applications: Flow Cytometry
• Clone: SPM533
• Dilution: Flow Cytometry
• Gene Symbols: MUC1
• Immunogen: Delipidated extract of human milk fat globule membranes
• Quantity: 0.1 mL
• Research Discipline: Cancer, Cellular Markers, Extracellular Matrix, Inflammation, Signal Transduction
• Gene ID (Entrez): 4582
• Target Species: Human
• Form: Purified

For Research Use Only