MUC4 Monoclonal Antibody (3C7.D8.E11.F), Rockland™

Mouse Monoclonal Antibody

Supplier:  Rockland Immunochemicals 200301GY2S

Catalog No. 50-199-0630

Description

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Directed against human MUC4 protein. A BLAST analysis was used to suggest cross reactivity with MUC4 from human based on 100% sequence homology with the immunogen. Reactivity with MUC4 from other sources is not known.

Nearly all mucosal surfaces are protected by mucin transmembrane glycoproteins, from bronchioles to corneas to reproductive tracts. Mucin 4 (MUC4) is membrane-bound and is important in protecting and lubricating. MUC4 expression is erroneous in many carcinomas and sarcomas, including fibromyoxoid sarcoma and pancreatic adenocarcinoma. Immunohistochemical staining for MUC4 has been discussed as a potential biomarker for detection of these cancers. MUC4 seems to be most predominantly affected in Asian diseases - Taiwanese infertility and endometriosis, as well as gallstone formation in Chinese men, are connected to MUC4, where similar diseases in other populations do not share these MUC4 mutations. Because MUC4 is so important in mucosal surface protection, it is not surprising that it has been implicated as failing in many metastatic cancer invasions.

Specifications

• Antigen: MUC4
• Classification: Monoclonal
• Concentration: 0.99 mg/mL
• Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
• Gene Accession No.: Q99102
• Gene Symbols: MUC4
• Immunogen: This protein A purified antibody was prepared from tissue culture supernate produced by repeated immunizations with a peptide corresponding to an internal portion of human Mucin-4.
• Regulatory Status: RUO
• Gene ID (Entrez): 4585
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Clone: 3C7.D8.E11.F
• Conjugate: Unconjugated
• Gene: MUC4
• Gene Alias: 4933405I11Rik; Ascites sialoglycoprotein; Ascites sialoglycoprotein 1; Ascites sialoglycoprotein 2; ASGP; ASGP1; ASGP-1; ASGP-2; HSA276359; MUC4; MUC-4; mucin 4; mucin 4, ASGP; mucin 4, cell surface associated; mucin 4, tracheobronchial; Mucin4; Mucin-4; Mucin-4 alpha chain; Mucin-4 beta chain; Pancreatic adenocarcinoma mucin; pre-sialomucin complex; Psmc; sialomucin ascites sialoglycoprotein-1; sialomucin complex; Testis mucin; Tracheobronchial mucin
• Host Species: Mouse
• Quantity: 25 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG