Invitrogen™ Munc13-4 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA518550

Catalog No. PIPA518550

Description

This antibody is predicted to react with bovine, canine, porcine and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.

This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.

Specifications

• Antigen: Munc13-4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Unc13d
• Gene Alias: 2610108D09Rik; FHL3; HLH3; HPLH3; Jinx; likely ortholog of H. sapiens unc-13 homolog D (UNC13D); mFLJ00067; munc 13-4; Munc13-4; Protein unc-13 homolog D; unc-13 homolog D; unc-13 homolog D (C. elegans); Unc13d
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 201294, 70450
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: B2RUP2, Q70J99
• Gene Symbols: Unc13d
• Immunogen: Synthetic peptide sequence (ETQKHKKDLHPLFD) corresponding to the internal amino acids of UNC13D (aa 967-980).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG