Invitrogen™ MUPP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA555378

Catalog No. PIPA555378

Description

Immunogen sequence: MIVRSIIHGG AISRDGRIAI GDCILSINEE STISVTNAQA RAMLRRHSLI GPDIKITYVP AEHLEEFKIS LGQQSGRVMA LDIFSSYTGR DIPELPEREE Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 91%.

MUPP1 (multi PDZ domain protein 1, MPDZ) was discovered as an interacting partner with the 5-HT2C receptor1, and was found to co-localize with 5-HT2A or 5-HT2C receptors in all regions of the mouse brain, including the choroid plexus. MUPP1 contains 13 PDZ domains but no apparent catalytic domain. MUPP1 is concentrated in tight junctions of polarized epithelial cells and binds to claudin-1 and junctional adhesion molecule (JAM). MUPP1 may therefore function as a multivalent scaffold protein that recruits various proteins to tight junctions. MUPP1 also interacts with claudin-8 and may play a role in tight junction barrier function.

Specifications

• Antigen: MUPP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MPDZ
• Gene Alias: AI225843; B930003D11Rik; DKFZp781P216; FLJ25909; FLJ34626; FLJ90240; HYC2; LOW QUALITY PROTEIN: multiple PDZ domain protein; MPDZ; Multi-PDZ domain protein 1; multiple PDZ domain crumbs cell polarity complex component; multiple PDZ domain protein; Mupp1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8777
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O75970
• Gene Symbols: MPDZ
• Immunogen: Recombinant protein corresponding to Human MUPP1. Recombinant protein control fragment (Product #RP-92908).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG