Murine anti-PON1, Clone: KRJ1, ZeptoMetrix

Murine Monoclonal Antibody

Supplier:  ZeptoMetrix 0801012

Catalog No. 22-158-012

Description

PON1 (arylesterase/paraoxonase) is a polymorphic enzyme closely associated with high-density lipoproteins (HDL). It is located on chromosome 7 along with 2 other paraoxanase genes, PON2 and PON3. It is a 355 amino acid, 43kDa glycoprotein produced in the liver and secreted into the bloodstream. Gene polymorphisms occur in both coding and non-coding regions. Two major polymorphisms in the coding region are L55M and Q192R. Q192R polymorphisms result in three major functional phenotypes Q/Q, Q/R and RR. PON1 hydrolyses organophosphates and prevents the oxidation of low-density lipoproteins (LDL). It may inhibit the progression of atherosclerosis by inhibition of LDL oxidation. Levels of PON1 in serum vary among individuals and are decreased in chronic renal failure, liver cirrhosis, diabetes, peripheral neuropathy, and familial hypercholesterolemia.

Specifications

• Antigen: PON1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG1

• Applications: Western Blot
• Clone: KRJ1
• Formulation: 100μg in PBS. No preservatives added.
• Immunogen: Partially purified PON1 from human plasma
• Quantity: 100 μg
• Primary or Secondary: Primary
• Content And Storage: Store at −10°C or below. Avoid freeze/thaw cycles. Thawed material may be stored at 4°C for short-term use.

For Research Use Only