Invitrogen™ MUSK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA527728

Catalog No. PIPA527728

Description

Recommended positive controls: NT2D1. Predicted reactivity: Mouse (97%), Rat (98%), Bovine (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

MUSK plays an important and selective role in many aspects of skeletal muscle development and function through the initial step of postsynaptic differentiation and formation of end-plate bands in cooperation with Rapsyn. Communication between cells is often mediated by receptors on the surface of the target cell that are triggered by specific ligands released by other cells. Receptor tyrosine kinase activity is strictly regulated by the binding of the appropriate ligand to the extracellular active site of the receptor. MuSK has been shown to be part of the agrin signaling complex and plays an important role in the development and architectural maintenance of the neuromuscular junction.

Specifications

• Antigen: MUSK
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MUSK
• Gene Alias: CMS9; FADS; Mdk4; MGC126323; MGC126324; Mlk; muscle associated receptor tyrosine kinase; muscle localized kinase 2; muscle specific kinase (neural fold/somite kinase 1); muscle, skeletal receptor tyrosine protein kinase; Muscle, skeletal receptor tyrosine-protein kinase; muscle, skeletal, receptor tyrosine kinase; muscle-specific kinase receptor; muscle-specific protein kinase secretory isoform; muscle-specific tyrosine kinase receptor MuSK; muscle-specific tyrosine protein kinase receptor; Muscle-specific tyrosine-protein kinase receptor; MuSK; Nsk1; Nsk2; Nsk3; RP23-170A3.1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4593
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: O15146
• Gene Symbols: MUSK
• Immunogen: Recombinant protein encompassing a sequence within the Extracellular domain of human MUSK. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG