Muskelin Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Catalog No.	Quantity
50-172-9682	150 μL

Catalog No. 50-172-9682 Supplier Proteintech Group Inc Supplier No. 147351AP150UL

Description

Rabbit Polyclonal Antibody

MAP kinase-interacting serine/threonine kinases (Mnk) function in signal transduction pathways through phosphorylation of eIF4E and are directly phosphorylated by ERK or p38 MAP kinases. In human and mouse there are two Mnk genes. Mnk1 is activated by phosphorylation at Thr197 and Thr202. Mnk1 and Mnk2 are essential for the phosphorylation of eIF4E at Ser209 however they differ markedly in their activity and regulatory patterns. Mnk1 is responsible for inducible phosphorylation of eIF4E while Mnk2 is responsible for basal levels of phosphorylation. Mnk1 has been implicated in signaling in response to oxidative stress by increasing eIF4E phosphorylation upon H2O2 treatment in mice. Oxidative stress induced Mnk1 activity has also been linked to hyperproliferative diseases through the over-activation of eIF4E. Reactivity with Mnk2 has not been tested.

Specifications

• Antigen: Muskelin
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 0.15 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: MKLN1
• Gene Accession No.: O89050, Q99PV3, Q9UL63
• Gene Alias: MKLN1, Muskelin, TWA2
• Gene Symbols: MKLN1
• Host Species: Rabbit
• Immunogen: Muskelin Fusion Protein Ag6147
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 27418, 4289, 83536
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG