Invitrogen™ MXI1 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA548047

Catalog No. PIPA548047

Description

In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) MAD1, rhMAD3, and rhMAD4 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

It is now well established that Myc regulation of cell proliferation and differentiation involves a family of related transcription factors. One such factor, Max, is an obligate heterodimeric partner for Myc and can also form heterodimers with at least four related proteins designated Mad 1, Mxi1, Mad 3 and Mad 4. Like Mad 1 and Mxi1, association of Mad 3 and Mad 4 with Max results in transcriptional repression. Both Myc and the Mad proteins have short half-lives and their synthesis is tightly regulated, while Max expression is constitutive and relatively stable. Two related mammalian cDNAs have been identified and shown to encode Mad-binding proteins. Both possess sequence homology with the yeast transcription repressor Sin3 including four conserved paired amphipathic helix (PAH) domains. mSin3A and mSin3B specifically interact with the Mad proteins via their second paired amphipathic helix domain (PAH2). It has been suggested that Mad-Max heterodimers repress transcription by tethering mSin3 to DNA as corepressors.

Specifications

• Antigen: MXI1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Mxi1
• Gene Alias: bHLHc11; class C basic helix-loop-helix protein 11; ENSMUSG00000067085; Gm10197; Mad2; MAX dimerization protein 2; Max interacting protein 1; MAX interactor 1; MAX interactor 1, dimerization protein; max-interacting protein 1; Max-interacting protein 1-like protein; Max-related transcription factor; MGC43220; MXD2; MXI; MXI1; MXI-WR; RP11-549L6.1
• Host Species: Goat
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4601
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: P50539
• Gene Symbols: Mxi1
• Immunogen: E. coli-derived recombinant human Mxi1 Ala81-Ser228.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG