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Invitrogen™ MXI1 Polyclonal Antibody
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Catalog No. PIPA557225
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100 μL
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PIPA557225 100 μL
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Catalog No. PIPA557225 Supplier Invitrogen™ Supplier No. PA557225
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: HTTLGLLNKA KAHIKKLEEA ERKSQHQLEN LEREQRFLKW RLEQLQGPQE MERIRM Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.

It is now well established that Myc regulation of cell proliferation and differentiation involves a family of related transcription factors. One such factor, Max, is an obligate heterodimeric partner for Myc and can also form heterodimers with at least four related proteins designated Mad 1, Mxi1, Mad 3 and Mad 4. Like Mad 1 and Mxi1, association of Mad 3 and Mad 4 with Max results in transcriptional repression. Both Myc and the Mad proteins have short half-lives and their synthesis is tightly regulated, while Max expression is constitutive and relatively stable. Two related mammalian cDNAs have been identified and shown to encode Mad-binding proteins. Both possess sequence homology with the yeast transcription repressor Sin3 including four conserved paired amphipathic helix (PAH) domains. mSin3A and mSin3B specifically interact with the Mad proteins via their second paired amphipathic helix domain (PAH2). It has been suggested that Mad-Max heterodimers repress transcription by tethering mSin3 to DNA as corepressors.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MXI1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Mxi1
Gene Accession No. P50539
Gene Alias bHLHc11; class C basic helix-loop-helix protein 11; ENSMUSG00000067085; Gm10197; Mad2; MAX dimerization protein 2; Max interacting protein 1; MAX interactor 1; MAX interactor 1, dimerization protein; max-interacting protein 1; Max-interacting protein 1-like protein; Max-related transcription factor; MGC43220; MXD2; MXI; MXI1; MXI-WR; RP11-549L6.1
Gene Symbols Mxi1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human MXI1. Recombinant protein control fragment (Product #RP-95284).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4601
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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