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MYC Mouse anti-Human, Clone: SPM237, Abnova™

Catalog No. 89934643 Shop All Abnova Corporation Products
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89-934-643 100 μg
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Catalog No. 89-934-643 Supplier Abnova Corporation Supplier No. MAB13122
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Description

Mouse monoclonal antibody raised against synthetic peptide of human MYC.

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq]

Sequence: AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA

Specifications

Antigen MYC
Applications Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed)
Classification Monoclonal
Clone SPM237
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against synthetic peptide of human MYC.
Dilution Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL) Immunofluorescence (1-2 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL) The optimal working dilution should be determined by the end user.
Formulation In 10mM PBS.
Gene Alias bHLHe39/c-Myc
Gene Symbols MYC
Host Species Mouse
Immunogen A synthetic peptide (conjugated with KLH) corresponding to amino acids 408-439 at C-terminus region of human MYC.
Purification Method Protein A/G purification
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4609
Target Species Human
Content And Storage Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
Isotype IgG1 κ
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