Invitrogen™ MYH7 Monoclonal Antibody (NOQ7.5.4D)

Catalog No.	Quantity
PIMA532986	100 μg

Catalog No. PIMA532986 Supplier Invitrogen™ Supplier No. MA532986

Description

Mouse Monoclonal Antibody

Reconstitute with 1 mL of PBS buffer to yield a concentration of 100 μg/mL. Positive Control - WB: rat heart tissue. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.

Specifications

• Antigen: MYH7
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: NOQ7.5.4D
• Concentration: 100 μg/mL
• Conjugate: Unconjugated
• Formulation: Ascites, 1.2% sodium acetate with 2mg BSA and 0.01mg sodium azide
• Gene: Myh7
• Gene Accession No.: P02564, P12883, Q91Z83
• Gene Alias: beta cardiac myosin heavy chain; beta myosin heavy chain; beta-MHC; beta-myosin; beta-myosin heavy chain; beta-myosin-heavy-chain; B-MHC; cardiac muscle myosin heavy chain 7 beta; cardiac myosin heavy chain beta isoform; CMD1S; CMH1; LOC100727138; mg:cb02g011; MPD1; Myh7; MYH-beta/slow; MyHC-alpha; Myhcb; Myhc-b; myHC-beta; MyHC-I; MyHC-slow; myopathy, distal 1; myosin beta heavy chain; myosin heavy chain 1; myosin heavy chain 7; myosin heavy chain cardiac alpha; myosin heavy chain polypeptide 7 cardiac muscle fetal; myosin heavy chain slow; myosin heavy chain slow isoform; myosin heavy chain slow type 1 (beta cardiac); myosin heavy chain, cardiac muscle beta isoform; myosin heavy chain, cardiac muscle, fetal; myosin heavy chain, polypeptide 7; myosin, heavy chain 7, cardiac muscle, beta; myosin, heavy polypeptide 7, cardiac muscle, beta; myosin-7; rhabdomyosarcoma antigen MU-RMS-40.7A; slow myosin heavy chain; smyhc3; SPMD; SPMM; type slow/beta myosin heavy chain; Unknown (protein for IMAGE:7985957); ventricular myosin heavy chain; vmhc
• Gene Symbols: Myh7
• Host Species: Mouse
• Immunogen: Human skeletal muscle myosin purified from myofibrils.
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 140781, 29557, 4625
• Target Species: Human, Mouse, Rat, Monkey
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG1

Safety and Handling

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