Invitrogen™ MYH7 Polyclonal Antibody

Catalog No.	Quantity
PA550240	100 μL

Catalog No. PA550240 Supplier Invitrogen™ Supplier No. PA550240

Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total Myosin-7 protein.

Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.

Specifications

• Antigen: MYH7
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene: Myh7
• Gene Accession No.: P12883
• Gene Alias: beta cardiac myosin heavy chain; beta myosin heavy chain; beta-MHC; beta-myosin; beta-myosin heavy chain; beta-myosin-heavy-chain; B-MHC; cardiac muscle myosin heavy chain 7 beta; cardiac myosin heavy chain beta isoform; CMD1S; CMH1; LOC100727138; mg:cb02g011; MPD1; Myh7; MYH-beta/slow; MyHC-alpha; Myhcb; Myhc-b; myHC-beta; MyHC-I; MyHC-slow; myopathy, distal 1; myosin beta heavy chain; myosin heavy chain 1; myosin heavy chain 7; myosin heavy chain cardiac alpha; myosin heavy chain polypeptide 7 cardiac muscle fetal; myosin heavy chain slow; myosin heavy chain slow isoform; myosin heavy chain slow type 1 (beta cardiac); myosin heavy chain, cardiac muscle beta isoform; myosin heavy chain, cardiac muscle, fetal; myosin heavy chain, polypeptide 7; myosin, heavy chain 7, cardiac muscle, beta; myosin, heavy polypeptide 7, cardiac muscle, beta; myosin-7; rhabdomyosarcoma antigen MU-RMS-40.7A; slow myosin heavy chain; smyhc3; SPMD; SPMM; type slow/beta myosin heavy chain; Unknown (protein for IMAGE:7985957); ventricular myosin heavy chain; vmhc
• Gene Symbols: Myh7
• Host Species: Rabbit
• Immunogen: Fusion protein corresponding to residues near the C terminal of human myosin, heavy chain 7, cardiac muscle, beta.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4625
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG