Myh9 Rabbit anti-Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-5873	Proteintech Group Inc 510531IG150UL	150 μL

Description

TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the -gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the -gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer′s disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased -gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate -gamma-secretase activity.

Specifications

• Antigen: Myh9
• Applications: ELISA
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Mouse
• Gene Accession No.: Q8VDD5
• Gene ID (Entrez): 17886
• Immunogen: Peptide
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: Myh9

• Concentration: 0.6 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: C80049, D0Jmb2, E030044M24Rik, Myh9, Myhn 1, Myhn1, TU72.6
• Gene Symbols: Myh9
• Isotype: IgG
• Purification Method: Protein A
• Product Type: Antibody