Invitrogen™ MYO1A Polyclonal Antibody

Catalog No.	Quantity
PIPA568236	100 μL

Catalog No. PIPA568236 Supplier Invitrogen™ Supplier No. PA568236

Description

Rabbit Polyclonal Antibody

Predicted to react with Mouse and Rat samples.

The protein encoded by this gene belongs to the myosin superfamily. Myosins are molecular motors that, upon interaction with actin filaments, utilize energy from ATP hydrolysis to generate mechanical force. Each myosin has a conserved N-terminal motor domain that contains both ATP-binding and actin-binding sequences. Following the motor domain is a light-chain-binding 'neck' region containing 1-6 copies of a repeat element, the IQ motif, that serves as a binding site for calmodulin or other members of the EF-hand superfamily of calcium-binding proteins. At the C-terminus, each myosin class has a distinct tail domain that serves in dimerization, membrane binding, protein binding, and/or enzymatic activities and targets each myosin to its particular subcellular location. The kidney epithelial cell line, LLC-PK1-CL4 (CL4), forms a well ordered brush border (BB) on its apical surface. Experiments indicate that the brush border population of the encoded protein turns over rapidly, while its head and tail domains interact transiently with the core actin and plasma membrane, respectively. A rapidly exchanging pool of the protein encoded by this gene envelops an actin core bundle that, by comparison, is static in structure.

Specifications

• Antigen: MYO1A
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: MYO1A
• Gene Accession No.: O88329, Q62774, Q9UBC5
• Gene Alias: BBMI; BBM-I; brush border myosin 1; brush border myosin I; brush border myosin-I; DFNA48; MIHC; Myh1; MYHL; Myo1a; myosin heavy polypeptide 1 skeletal muscle adult; myosin I heavy chain; myosin IA; myosin, heavy polypeptide-like (100kD); myosin, heavy polypeptide-like (110kD); myosin-Ia; unconventional myosin-Ia
• Gene Symbols: MYO1A
• Host Species: Rabbit
• Immunogen: Synthesized peptide derived from human MYO1A.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 299509, 432516, 4640
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov