Invitrogen™ MYOM1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5100626

Catalog No. PIPA5100626

Description

Antibody detects endogenous levels of total MYOM1.

The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2). This protein, myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region. The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.

Specifications

• Antigen: MYOM1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Myom1
• Gene Alias: 190 kDa connectin-associated protein; 190 kDa titin-associated protein; D430047A17Rik; EH-myomesin; MYOM1; myomesin (M-protein) 1 (190kD); myomesin 1; myomesin 1 (skelemin) 185kDa; myomesin 1, 185kDa; myomesin family member 1; Myomesin-1; skelemin
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 17929, 316740, 8736
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P52179, Q62234
• Gene Symbols: Myom1
• Immunogen: A synthesized peptide derived from human MYOM1(Accession P52179), corresponding to amino acid residues D764-V814.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG