MilliporeSigma™ Myosin-3 (MYH3), Mouse, Unlabeled, Clone: BF-G6,

Catalog No.	Quantity	Conjugate
MABT818MI	100 μg	Unconjugated

Catalog No. MABT818MI Supplier MilliporeSigma™ Supplier No. MABT818

Description

Mouse Monoclonal Antibody

Myosin-3 (UniProt A6QPA6; also known as Muscle embryonic myosin heavy chain, Myosin heavy chain 3, MYH3, Protein, Myosin heavy chain, fast skeletal muscle, embryonic, SMHCE) is encoded by the MYH3 gene (Gene ID 281338) in bovine species. Myosin is a major contractile protein that converts chemical energy into mechanical energy through the hydrolysis of ATP. MYH3 is predominantly expressed during fetal development and its expression declines rapidly after birth. It is not normally present in adult muscle except during muscle regeneration. Mutations in MYH3 are known cause two congenital contracture syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome, the most severe forms of distal arthrogryposis (DA). Ref.: Pokrzywa, M., et al. (2015). PLoS One. 10(11):e0142094; Toydamir, R.M., et al. (2006). Nature Genet. 38(5):561-565.

Specifications

• Antigen: Myosin-3 (MYH3)
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
• Classification: Monoclonal
• Clone: BF-G6
• Concentration: Please refer to lot specific datasheet.
• Conjugate: Unconjugated
• Formulation: Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
• Gene: MYH3
• Gene Accession No.: A6QPA6
• Host Species: Mouse
• Immunogen: Fetal bovine skeletal muscle myosin (Schiaffino, S., et al. (1986). Exp. Cell Res. 163(1):211-220).
• Purification Method: Protein G Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Cell Structure
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_001095305
• Test Specificity: Clone BF-G6 detected myosin in human fetal muscle, but not adult human skeletal muscle tissue (Schiaffino, S., et al. (1986). Exp. Cell Res. 163(1):211-220).
• Target Species: Human
• Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
• Form: Purified
• Isotype: IgG1 κ

For Research Use Only. Not for use in diagnostic procedures.