MilliporeSigma™ Myosin-3 (MYH3), Mouse, Unlabeled, Clone: BF-G6,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABT818

Catalog No. MABT818MI

Description

Myosin-3 (UniProt A6QPA6; also known as Muscle embryonic myosin heavy chain, Myosin heavy chain 3, MYH3, Protein, Myosin heavy chain, fast skeletal muscle, embryonic, SMHCE) is encoded by the MYH3 gene (Gene ID 281338) in bovine species. Myosin is a major contractile protein that converts chemical energy into mechanical energy through the hydrolysis of ATP. MYH3 is predominantly expressed during fetal development and its expression declines rapidly after birth. It is not normally present in adult muscle except during muscle regeneration. Mutations in MYH3 are known cause two congenital contracture syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome, the most severe forms of distal arthrogryposis (DA). Ref.: Pokrzywa, M., et al. (2015). PLoS One. 10(11):e0142094; Toydamir, R.M., et al. (2006). Nature Genet. 38(5):561-565.

Specifications

• Antigen: Myosin-3 (MYH3)
• Classification: Monoclonal
• Concentration: Please refer to lot specific datasheet.
• Formulation: Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
• Gene Accession No.: A6QPA6
• Immunogen: Fetal bovine skeletal muscle myosin (Schiaffino, S., et al. (1986). Exp. Cell Res. 163(1):211-220).
• Quantity: 100 μg
• Research Discipline: Cell Structure
• Gene ID (Entrez): NP_001095305
• Target Species: Human
• Form: Purified

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
• Clone: BF-G6
• Conjugate: Unconjugated
• Gene: MYH3
• Host Species: Mouse
• Purification Method: Protein G Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Clone BF-G6 detected myosin in human fetal muscle, but not adult human skeletal muscle tissue (Schiaffino, S., et al. (1986). Exp. Cell Res. 163(1):211-220).
• Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
• Isotype: IgG1 κ

For Research Use Only. Not for use in diagnostic procedures.