Invitrogen™ MZB1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA560493

Catalog No. PIPA560493

Description

Immunogen sequence: YGVREVDQVK RLTGPGLSEG PEPSISVMVT GGPWPTRLSR TCLHYLGEFG EDQIYEAHQQ GRGALEALLC GGPQGACSEK VSATR Highest antigen sequence identity to the following orthologs: Mouse - 73%, Rat - 74%.

MZB1 associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation.; Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.

Specifications

• Antigen: MZB1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MZB1
• Gene Alias: caspase-2 binding protein; HSPC190; marginal zone B and B1 cell specific protein; marginal zone B and B1 cell-specific protein; marginal zone B- and B1-cell-specific protein; MEDA7; MEDA-7; Mesenteric estrogen-dependent adipose 7; mesenteric oestrogen-dependent adipose gene- 7; MGC29506; MZB1; PACAP; pERp1; plasma cell-induced ER protein 1; plasma cell-induced resident endoplasmic reticulum protein; Plasma cell-induced resident ER protein; proapoptotic caspase adapter protein; proapoptotic caspase adaptor protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51237
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.10 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8WU39
• Gene Symbols: MZB1
• Immunogen: Recombinant protein corresponding to Human MZB1. Recombinant protein control fragment (Product #RP-100226).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG