N-Ethylmaleimide, 98+%

Description

CAS: 128-53-0 | C6H7NO2 | 125.127 g/mol

Cysteine alkylating agent N-Ethylmaleimide is a protein thiol modifier which inhibits apoptotic DNA fragmentation. It is a sulfhydryl reagent and finds application in experimental biochemical studies as well as in enzymology. It is involved in the modification of cysteine residues in proteins and peptides. It acts as a Michael acceptor and reacts with nucelophiles like thiols. It is employed in the inhibition of Mg²⁺-dependent internucleosomal DNA fragmentation.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Cysteine alkylating agent N-Ethylmaleimide is a protein thiol modifier which inhibits apoptotic DNA fragmentation. It is a sulfhydryl reagent and finds application in experimental biochemical studies as well as in enzymology. It is involved in the modification of cysteine residues in proteins and peptides. It acts as a Michael acceptor and reacts with nucelophiles like thiols. It is employed in the inhibition of Mg²⁺-dependent internucleosomal DNA fragmentation.

Solubility
Soluble in ethanol, water, chloroform, methanol and toluene.

Notes
Light sensitive. Store in cool place. Incompatible with strong oxidizing agents, strong acids and strong bases.

Specifications

Chemical Identifiers

• CAS: 128-53-0
• Molecular Formula: C6H7NO2
• Molecular Weight (g/mol): 125.127
• MDL Number: MFCD00005509
• InChI Key: HDFGOPSGAURCEO-UHFFFAOYSA-N
• Synonym: n-ethylmaleimide, ethylmaleimide, 1-ethyl-1h-pyrrole-2,5-dione, maleimide, n-ethyl, 1h-pyrrole-2,5-dione, 1-ethyl, maleic acid n-ethylimide, nem, usaf b-121, unii-o3c74acm9v, maleic acid-n-ethylimide
• PubChem CID: 4362
• ChEBI: CHEBI:44485
• IUPAC Name: 1-ethylpyrrole-2,5-dione
• SMILES: CCN1C(=O)C=CC1=O

• Melting Point: 43°C to 46°C
• Boiling Point: 209°C to 211°C
• Flash Point: 73°C (163°F)
• Odor: Pungent
• Quantity: 10 g
• UN Number: UN2928
• Beilstein: 112448
• Sensitivity: Light sensitive
• Merck Index: 14,3822
• Solubility Information: Soluble in ethanol,water,chloroform,methanol and toluene.
• Formula Weight: 125.13
• Percent Purity: ≥98%
• Chemical Name or Material: N-Ethylmaleimide

Safety and Handling

Hazard Category	H300-H311-H314-H317-H335
Hazard Statement	GHS H Statement H300-H311-H314-H318-H317 Fatal if swallowed. Toxic in contact with skin. Causes severe skin burns and eye damage. Causes serious eye damage. May cause an allergic skin reaction.
Precautionary Statement	P260-P264b-P270-P271-P272-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P333+P313-P363-P501c
DOTInformation	Transport Hazard Class: 6.1; Packing Group: II; Proper Shipping Name: TOXIC SOLIDS, CORROSIVE, ORGANIC, N.O.S.
EINECSNumber	204-892-4
RTECSNumber	UX9625000
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only