Invitrogen™ N-WASP Recombinant Rabbit Monoclonal Antibody (4P5M9)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA535352

Catalog No. PIMA535352

Description

Immunogen sequence: LPSSAPSGPP PPPPSVLGVG PVAPPPPPPP PPPPGPPPPP GLPSDGDHQV PTTAGNKAAL LDQIREGAQL KKVEQNSRPV SCSGRDALLD QIRQGIQLKS V.

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes.

Specifications

• Antigen: N-WASP
• Classification: Recombinant Monoclonal
• Concentration: 1.8 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O00401, O08816, Q91YD9
• Gene Symbols: WASL
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 350-450 of human N-WASP/WASL (O00401).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Clone: 4P5M9
• Conjugate: Unconjugated
• Gene: WASL
• Gene Alias: 2900021I12Rik; 3110031I02Rik; DKFZp779G0847; MGC48327; n wasp; neural Wiskott-Aldrich syndrome protein; NWASP; N-WASP; TRS4; WASL; WASP like actin nucleation promoting factor; WASPB; Wiskott-Aldrich syndrome like; Wiskott-Aldrich syndrome-like; Wiskott-Aldrich syndrome-like (human)
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 682507, 73178, 8976
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid