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Invitrogen™ N-WASP Recombinant Rabbit Monoclonal Antibody (4P5M9)
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Catalog No. PIMA535352
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PIMA535352 100 μL
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Catalog No. PIMA535352 Supplier Invitrogen™ Supplier No. MA535352
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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: LPSSAPSGPP PPPPSVLGVG PVAPPPPPPP PPPPGPPPPP GLPSDGDHQV PTTAGNKAAL LDQIREGAQL KKVEQNSRPV SCSGRDALLD QIRQGIQLKS V.

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes.
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Specifications

Antigen N-WASP
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone 4P5M9
Concentration 1.8 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene WASL
Gene Accession No. O00401, O08816, Q91YD9
Gene Alias 2900021I12Rik; 3110031I02Rik; DKFZp779G0847; MGC48327; n wasp; neural Wiskott-Aldrich syndrome protein; NWASP; N-WASP; TRS4; WASL; WASP like actin nucleation promoting factor; WASPB; Wiskott-Aldrich syndrome like; Wiskott-Aldrich syndrome-like; Wiskott-Aldrich syndrome-like (human)
Gene Symbols WASL
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 350-450 of human N-WASP/WASL (O00401).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 682507, 73178, 8976
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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