Invitrogen™ N4BP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5117135

Catalog No. PIPA5117135

Description

Positive Samples: Jurkat, 293T, Mouse brain, Mouse pancreas Immunogen sequence: TQGEESLFET DDDVITVGDV RPPEYTQSAA TGPSSARDEV VVQEDSRNKA RTPVSELTKH MDTVFSSSPD VLFVPVNGLS PDEDALSKDR VCHKRRSSDT EERHTKKQFS LENVPEGELL PDGKGSAGNE VIDLSDPASN STNLSPDGKD TTEEMEYNIL VNFFKTMGYS QEIVEKVIRE YGPSTEPLLL LEEIEKENKR LQEDRDFPPC TVYPDASQSR NAGVGSTTNE LTADSTPKKA QSHTEQSMVE RFSQLPFKDS KHCTSNCKVN SFRTVPVGQK QEIWGSKQNS SCTVDLETDG HSASAASASP KDISFVSRGA SGHQQRNPAF PENGFQQQTE PLLPNNTKPA CEKRSGSCSS PQPKPNYPPL SPPLPLPQLL PSVTEARLGG SSDHIDSSVT G.

Nedd4-binding partner-1 (N4BP1) is a developmentally expressed protein interactor and monoubiquitylation substrate of Nedd4, a HECT domain-containing ubiquitin ligase that mediates ubiquitylation and proteasome degradation of target proteins and may have a fundamental role to play in embryonic processes. N4BP1 can undergo Nedd4-mediated polyubiquitylation and proteosomal degradation. N4BP1 also functions as a negative regulator of AIF4 (also known as ITCH or Atrophin-1), an E3-ubiquitin ligase, by interacting with the second WW domain of AIF4 and impairing ubiquitination of substrates.

Specifications

• Antigen: N4BP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: N4BP1
• Gene Alias: AI481586; C81621; Kiaa0615; N4BP1; Nedd4 binding protein 1; NEDD4-binding protein 1; RGD1305179
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 80750, 9683
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 0.91 mg/mL
• Formulation: PBS with 0.02% sodium azide; pH 7.3
• Gene Accession No.: O75113, Q6A037
• Gene Symbols: N4BP1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 190-590 of mouse N4BP1 (NP_0850402).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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