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N4BP2L2 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA539341

Catalog No. PIPA539341


Description

Description

N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5 (phosphonoformate immuno-associated protein 5), is a 583 amino acid nuclear protein that potentially is involved in transcriptional regulation. N4BP2L2 is phosphorylated on Ser 199 in response to DNA damage, probably by ATM or ATR. Primarily expressed in bone marrow, N4BP2L2 is dramatically down-regulated after exposure to arsenic compounds, an event which precedes neutropenia. PFAAP5 interacts with both Gfi-1 and Neutrophil Elastase, two proteins that are implicated in neutropenia disorders. Defects in the gene encoding Neutrophil Elastase, ELA2, are the cause of cyclic haematopoiesis, which, with decreased numbers of circulating neutrophils, leads to an increased risk for opportunistic infection.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

N4BP2L2
Polyclonal
Unconjugated
N4BP2L2
NEDD4-binding protein 2-like 2, Phosphonoformate immuno-associated protein 5, CG005, PFAAP5
Rabbit
Antigen affinity chromatography
RUO
10443, 381695
-20°C
Liquid
Western Blot
1 mg/mL
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
Q92802, Q8JZS6
N4BP2L2
A synthetic peptide derived from the internal region of human N4BP2L2
100 μg
Primary
Human, Mouse
Antibody
IgG
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