Invitrogen™ N4BP2L2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5101750

Catalog No. PIPA5101750

Description

Antibody detects endogenous levels of total N4BP2L2.

N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5 (phosphonoformate immuno-associated protein 5), is a 583 amino acid nuclear protein that potentially is involved in transcriptional regulation. N4BP2L2 is phosphorylated on Ser 199 in response to DNA damage, probably by ATM or ATR. Primarily expressed in bone marrow, N4BP2L2 is dramatically down-regulated after exposure to arsenic compounds, an event which precedes neutropenia. PFAAP5 interacts with both Gfi-1 and Neutrophil Elastase, two proteins that are implicated in neutropenia disorders. Defects in the gene encoding Neutrophil Elastase, ELA2, are the cause of cyclic haematopoiesis, which, with decreased numbers of circulating neutrophils, leads to an increased risk for opportunistic infection.

Specifications

• Antigen: N4BP2L2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: N4BP2L2
• Gene Alias: 2700092H06Rik; 92M18.3; CG005; CG016; N4BP2L2; NEDD4 binding protein 2 like 2; NEDD4 binding protein 2-like 2; NEDD4-binding protein 2-like 2; PFAAP5; phosphonoformate immuno-associated protein 5; Phosphonoformate immuno-associated protein 5 homolog; protein from BRCA2 region; zag1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10443, 381695
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q8JZS6, Q92802
• Gene Symbols: N4BP2L2
• Immunogen: A synthesized peptide derived from human N4BP2L2(Accession Q92802), corresponding to amino acid residues D358-R408.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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