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Invitrogen™ N6AMT2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA5113139
Description
N6AMT2 Polyclonal Antibody for Western Blot, ELISA
Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. Dnmt2 contains all the sequence motifs diagnostic of DNA (cytosine-5)-methyltransferases but appears to lack the large N-terminal regulatory domain common to other eukaryotic methyltransferases.
Specifications
N6AMT2 | |
Polyclonal | |
Unconjugated | |
Eef1akmt1 | |
2510005D08Rik; AW045965; Ayu21-96; DMNT2; DNMT2; EEF1A lysine methyltransferase 1; Eef1akmt1; ESP13; eukaryotic translation elongation factor 1 alpha lysine methyltransferase 1; Gt(Ayu21)96Imeg; Gt(pU21)96Imeg; GtAyu21-96; M.HsaIIP; N(6)-adenine-specific DNA methyltransferase 2; N-6 adenine-specific DNA methyltransferase 2 (putative); N6AMT2; Protein-lysine N-methyltransferase N6AMT2; PuMet; RGD1306762; RNMT1; RP11-406H21.1 | |
Rabbit | |
Protein G | |
RUO | |
221143 | |
-20°C or -80°C if preferred | |
Liquid |
ELISA, Western Blot | |
5 mg/mL | |
PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4 | |
Q8WVE0 | |
Eef1akmt1 | |
Recombinant Human EEF1A lysine methyltransferase 1 protein (2-214AA). | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG |
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