Invitrogen™ N6AMT2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5113139

Catalog No. PIPA5113139

Description

N6AMT2 Polyclonal Antibody for Western Blot, ELISA

Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. Dnmt2 contains all the sequence motifs diagnostic of DNA (cytosine-5)-methyltransferases but appears to lack the large N-terminal regulatory domain common to other eukaryotic methyltransferases.

Specifications

• Antigen: N6AMT2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Eef1akmt1
• Gene Alias: 2510005D08Rik; AW045965; Ayu21-96; DMNT2; DNMT2; EEF1A lysine methyltransferase 1; Eef1akmt1; ESP13; eukaryotic translation elongation factor 1 alpha lysine methyltransferase 1; Gt(Ayu21)96Imeg; Gt(pU21)96Imeg; GtAyu21-96; M.HsaIIP; N(6)-adenine-specific DNA methyltransferase 2; N-6 adenine-specific DNA methyltransferase 2 (putative); N6AMT2; Protein-lysine N-methyltransferase N6AMT2; PuMet; RGD1306762; RNMT1; RP11-406H21.1
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 221143
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 5 mg/mL
• Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
• Gene Accession No.: Q8WVE0
• Gene Symbols: Eef1akmt1
• Immunogen: Recombinant Human EEF1A lysine methyltransferase 1 protein (2-214AA).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG