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Invitrogen™ NAB2 Polyclonal Antibody
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Catalog No. PIPA5120954
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100 μL
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PIPA5120954 100 μL
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Catalog No. PIPA5120954 Supplier Invitrogen™ Supplier No. PA5120954
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Description

Rabbit Polyclonal Antibody

Positive test controls include: M21, Mouse lung, Mouse liver. The target is usually found in the following locations: Nucleus. Immunogen sequence: MHRAPSPTAE QPPGGGDSAR RTLQPRLKPS ARAMALPRTL GELQLYRVLQ RANLLSYYET FIQQGGDDVQ QLCEAGEEEF LEIMALVGMA TKPLHVRRLQ KALREWATNP GLFSQPVPAV PVSSIPLFKI SETAGTRKGS MSNGHGSPGE KAGSARSFSP KSPLELGEKL SPLPGGPGAG DPRIWPGRST PESDVGAGGE.

Transcriptional control is in part regulated by interactions between DNA-bound transcription factors, such as Egr-1/NGFI-A, and coregulatory proteins, such as NAB (for NGFI-A-binding proteins). The evolutionarily conserved NAB proteins, NAB1 and NAB2, are corepressors of EGF-1/NGFI-A. Both NAB1 and NAB2 contain an amino terminal NAB conserved domain 1 (NCB1), which is required for binding NGFI-A, and a carboxy terminal NCD2 domain, which is responsible for the repressor function of NAB proteins. NAB2 is principally localized in the nucleus and may play a role in the downregulation of NGFI-A activity as well as in controlling fundamental processes such as cell division, differentiation and apoptosis. NAB2 has a predicted molecular mass of 56 kDa and localizes to chromosome 12q13.3-14.1, a region that is rearranged in several solid tumors, lipomas and liposarcomas.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NAB2
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.36 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene NAB2
Gene Accession No. Q15742, Q61127
Gene Alias AI451907; EGR1 binding protein 2; EGR-1-binding protein 2; MADER; Melanoma-associated delayed early response protein; NAB2; NGFI-A binding protein 2; NGFI-A binding protein 2 (EGR1 binding protein 2); NGFI-A binding protein 2 (EGR-1 binding protein 2); NGFI-A-binding protein 2; Protein MADER
Gene Symbols NAB2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human NAB2 (NP_005958.1).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17937, 4665
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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