Invitrogen™ NAB2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA530096

Catalog No. PIPA530096

Description

Recommended positive controls: 293T, A431, Jurkat, Raji. Predicted reactivity: Mouse (93%), Rat (96%), Rhesus Monkey (100%), Bovine (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Transcriptional control is in part regulated by interactions between DNA-bound transcription factors, such as Egr-1/NGFI-A, and coregulatory proteins, such as NAB (for NGFI-A-binding proteins). The evolutionarily conserved NAB proteins, NAB1 and NAB2, are corepressors of EGF-1/NGFI-A. Both NAB1 and NAB2 contain an amino terminal NAB conserved domain 1 (NCB1), which is required for binding NGFI-A, and a carboxy terminal NCD2 domain, which is responsible for the repressor function of NAB proteins. NAB2 is principally localized in the nucleus and may play a role in the downregulation of NGFI-A activity as well as in controlling fundamental processes such as cell division, differentiation and apoptosis. NAB2 has a predicted molecular mass of 56 kDa and localizes to chromosome 12q13.3-14.1, a region that is rearranged in several solid tumors, lipomas and liposarcomas.

Specifications

• Antigen: NAB2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NAB2
• Gene Alias: AI451907; EGR1 binding protein 2; EGR-1-binding protein 2; MADER; Melanoma-associated delayed early response protein; NAB2; NGFI-A binding protein 2; NGFI-A binding protein 2 (EGR1 binding protein 2); NGFI-A binding protein 2 (EGR-1 binding protein 2); NGFI-A-binding protein 2; Protein MADER
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4665
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunoprecipitation, Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q15742
• Gene Symbols: NAB2
• Immunogen: Recombinant fragment corresponding to a region within amino acids 196 and 420 of Human NAB2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG