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Invitrogen™ NAB2 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA530096
Description
Recommended positive controls: 293T, A431, Jurkat, Raji. Predicted reactivity: Mouse (93%), Rat (96%), Rhesus Monkey (100%), Bovine (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Transcriptional control is in part regulated by interactions between DNA-bound transcription factors, such as Egr-1/NGFI-A, and coregulatory proteins, such as NAB (for NGFI-A-binding proteins). The evolutionarily conserved NAB proteins, NAB1 and NAB2, are corepressors of EGF-1/NGFI-A. Both NAB1 and NAB2 contain an amino terminal NAB conserved domain 1 (NCB1), which is required for binding NGFI-A, and a carboxy terminal NCD2 domain, which is responsible for the repressor function of NAB proteins. NAB2 is principally localized in the nucleus and may play a role in the downregulation of NGFI-A activity as well as in controlling fundamental processes such as cell division, differentiation and apoptosis. NAB2 has a predicted molecular mass of 56 kDa and localizes to chromosome 12q13.3-14.1, a region that is rearranged in several solid tumors, lipomas and liposarcomas.
Specifications
NAB2 | |
Polyclonal | |
Unconjugated | |
NAB2 | |
AI451907; EGR1 binding protein 2; EGR-1-binding protein 2; MADER; Melanoma-associated delayed early response protein; NAB2; NGFI-A binding protein 2; NGFI-A binding protein 2 (EGR1 binding protein 2); NGFI-A binding protein 2 (EGR-1 binding protein 2); NGFI-A-binding protein 2; Protein MADER | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
4665 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunoprecipitation, Western Blot | |
1 mg/mL | |
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7 | |
Q15742 | |
NAB2 | |
Recombinant fragment corresponding to a region within amino acids 196 and 420 of Human NAB2. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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