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Invitrogen™ NACA Polyclonal Antibody
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Catalog No. PIPA5116506
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100 μL
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PIPA5116506 100 μL
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Catalog No. PIPA5116506 Supplier Invitrogen™ Supplier No. PA5116506
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Description

Rabbit Polyclonal Antibody

Positive Samples: HL-60, SW620, 293T, U-87MG, HeLa, Mouse liver, Mouse kidney, Mouse brain, Rat brain Immunogen sequence: MPGEATETVP ATEQELPQPQ AETGSGTESD SDESVPELEE QDSTQATTQQ AQLAAAAEID EEPVSKAKQS RSEKKARKAM SKLGLRQVTG VTRVTIRKSK NILFVITKPD VYKSPASDTY IVFGEAKIED LSQQAQLAAA EKFKVQGEAV SNIQENTQTP TVQEESEEEE VDETGVEVKD IELVMSQANV SRAKAVRALK NNSNDIVNAI MELTM.

NACA prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). It binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. NACA also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites), and may act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NACA
Applications ELISA, Western Blot, Western Blot
Classification Polyclonal
Concentration 0.22 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene NACA
Gene Accession No. E9PAV3, P70670, Q13765, Q60817
Gene Alias AL022831; AL024382; Alpha-NAC; Alpha-NAC, muscle-specific form; alpha-NAC/1.9.2; Gm1878; Hom s 2; HSD48; mKIAA0363; NACA; NACA1; NAC-alpha; nascent polypeptide-associated complex alpha polypeptide; nascent polypeptide-associated complex alpha subunit; nascent polypeptide-associated complex subunit alpha; Nascent polypeptide-associated complex subunit alpha, muscle-specific form; nascent-polypeptide-associated complex alpha polypeptide; skNAC
Gene Symbols NACA
Host Species Rabbit
Immunogen Recombinant protein (or fragment)
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17938, 288770, 4666
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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