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Invitrogen™ NADK Polyclonal Antibody
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Catalog No. PIPA565779
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100 μL
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PIPA565779 100 μL
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Catalog No. PIPA565779 Supplier Invitrogen™ Supplier No. PA565779
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: VYVEKKVLEDP AIASDESFGA VKKKFCTFRE DYDDISNQID FIICLGGDGT LLYASSLFQG SVPPVMAFHL GSLGFLTPFS FENFQS Highest antigen sequence identity to the following orthologs - mouse 95%, rat 94%.

NADK (Nicotinamide Adenine Dinucleotide Kinase) is an enzyme crucial in the regulation of intracellular NADP+ levels, which are necessary for metabolic processes such as fatty acid and DNA synthesis. The human NADK gene is located on chromosome 1p36.33 and encodes a protein that primarily functions in the cytoplasm. NADK catalyzes the phosphorylation of NAD+ to NADP+, playing a significant role in maintaining the cellular redox state. Structurally, human NADK forms a dimeric organization, as revealed by its crystal structure, and includes four subunits (chains A-D) with specific colors indicating different chains. The enzyme's activity is regulated post-translationally, but its pathophysiological significance in humans remains underexplored. Multiple orthologs of the NADK gene are present in various organisms, illustrating its evolutionary conservation and importance across different species.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NADK
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene NADK
Gene Accession No. O95544
Gene Alias 4432404C02Rik; BC004012; dJ283E3.1; FLJ13052; hypothetical protein LOC513419; LOW QUALITY PROTEIN: NAD kinase; NAD kinase; Nadk; Poly(P)/ATP NAD kinase; ppnk; Putative inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase)
Gene Symbols NADK
Host Species Rabbit
Immunogen Recombinant Human NADK. Recombinant protein control fragment (Product #RP-106458).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 65220
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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