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NADPH oxidase 4 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501981001
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Catalog No. Quantity
50-198-1001 100 μL
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Catalog No. 50-198-1001 Supplier Bioss Supplier No. BS1091R
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Description

Rabbit Polyclonal Antibody

Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggests that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.

Specifications

Antigen NADPH oxidase 4
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Nox4
Gene Accession No. Q9NPH5
Gene Alias AI648021; BOS_24390; Kidney oxidase-1; Kidney superoxide-producing NADPH oxidase; Kox; KOX1; KOX-1; NADPH oxidase 4; NOX4; Renal NAD(P)H-oxidase; Renox; Superoxide-generating NADPH oxidase 4
Gene Symbols Nox4
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from mouse Nox-4 .
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 50507
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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