Invitrogen™ NAGA Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA597299

Catalog No. PIPA597299

Description

Immunogen sequence: IQGRRIHKEK SLIEVYMRPL SNKASALVFF SCRTDMPYRY HSSLGQLNFT GSVIYEAQDV YSGDIISGLR DETNFTVIIN PSGVVMWYLY PIKNLEMSQQ; Positive Samples: HL-60, Mouse liver, Mouse kidney, Mouse lung, Rat testis; Cellular Location: Lysosome.

NAGA (N-acetylgalactosaminidase, alpha), also known as alpha-galactosidase B or GALB, is a 411 lysosomal protein belonging to the glycosyl hydrolase 27 family that may exist as a homodimer and plays a critical role in glycolipid breakdown. NAGA encodes alpha-N-acetylgalactosaminidase, a lysosomal enzyme, which cleaves alpha-N-acetylgalactosaminyl groups from glycoconjugates. Mapping to human chromosome 22q13. 2, NAGA defects are the cause of an autosomal recessive disorder with three phenotypes, known as Schindler disease (types I, II and III) or NAGA deficiency (types I, II and III). Characterized by neurologic manifestations that range in severity, Schindler disease type I is the most severe form, followed by type III, which may have mild-to-moderate effects. Schindler disease type II, also known as Kanzaki disease, is characterized by mild intellectual impairment and angiokeratoma corporis diffusum.

Specifications

• Antigen: NAGA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NAGA
• Gene Alias: Acetylgalactosaminidase, alpha-N- (alpha-galactosidase B); alpha-galactosidase B; Alpha-N-acetylgalactosaminidase; D22S674; EC 3.2.1; EC 3.2.1.49; galactosidasealphaB; galactosidase-alphaB; GALB; N-acetyl galactosaminidase, alpha; N-acetylgalactosaminidase, alpha-; Naga
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 17939, 315165, 4668
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 0.99 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P17050, Q66H12, Q9QWR8
• Gene Symbols: NAGA
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 312-411 of human NAGA (NP_0002531).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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