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Invitrogen™ NAGPA Polyclonal Antibody
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Catalog No. PIPA564149
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100 μL
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PIPA564149 100 μL
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Catalog No. PIPA564149 Supplier Invitrogen™ Supplier No. PA564149
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FFRMNSGECL GNVVSDERRV SSSGGLQNAQ FGIRRDGTLV TGYLSEEEVL DTENPFVQLL SGVVWLIRNG SIYINESQAT ECDETQETGS FSKFVNVISA RTAIGHDRKG QLVLFHADGQ TEQRGINLWE MAE Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 92%.

Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. The encoded preproprotein is proteolytically processed by furin to generate the mature enzyme, a homotetramer of two disulfide-linked homodimers. Mutations in this gene are associated with developmental stuttering in human patients.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NAGPA
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene NAGPA
Gene Accession No. Q9UK23
Gene Alias AI596180; alpha-GlcNAcase; alpha-N-acetylglucosaminyl phosphodiesterase; APAA; lysosomal alpha-N-acetylglucosaminidase; mannose 6-phosphate-uncovering enzyme; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; NAGPA; Phosphodiester alpha-GlcNAcase; UCE; zgc:165534
Gene Symbols NAGPA
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human NAGPA. Recombinant protein control fragment (Product #RP-103542).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51172
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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