Invitrogen™ NALP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5111579

Catalog No. PIPA5111579

Description

Immunogen sequence: CVWDQFLGEI NPQHSWMVAG PLLDIKAEPG AVEAVHLPHF VALQGGHVDT SLFQMAHFKE EGMLLEKPAR VELHHIVLEN PSFSPLGVLL KMIHNALRFI PVTSVVLLYH RVHPEEVTFH LYLIPSDCSI RK.

NALP1 is a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.

Specifications

• Antigen: NALP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NLRP1
• Gene Alias: CARD7; caspase recruitment domain protein; caspase recruitment domain protein 7; caspase recruitment domain-containing protein 7; CIDED; CLR17.1; death effector filament-forming Ced-4-like apoptosis protein; DEFCAP; DEFCAP-L/S; DKFZp586O1822; Gm14; Gm15; KIAA0926; NAC; nacht; NACHT, leucine rich repeat and PYD (pyrin domain) containing 1; NACHT, leucine rich repeat and PYD containing 1; NACHT, LRR and PYD containing protein 1; NACHT, LRR and PYD domains-containing protein 1; NACHT, LRR and PYD domains-containing protein 1a; NACHT/LRR/pyrin domain-containing protein 1; Nalp1; Nalp1a; NLR family protein 1; NLR family pyrin domain containing 1; NLR family, pyrin domain containing 1; NLR family, pyrin domain containing 1A; Nlrp1; Nlrp1a; Nucleotide-binding domain and caspase recruitment domain; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1; PP1044; resistant anthrax lethal toxin; SLEV1; VAMAS1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22861
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.20 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9C000
• Gene Symbols: NLRP1
• Immunogen: Recombinant Protein corresonding to Human NALP1. Recombinant protein control fragment (Product #RP-107337).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG