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Invitrogen™ NALP10 Monoclonal Antibody (578502)
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Catalog No. PIMA524260
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100 μg
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PIMA524260 100 μg
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Catalog No. PIMA524260 Supplier Invitrogen™ Supplier No. MA524260
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Description

Mouse Monoclonal Antibody

In direct ELISAs, no cross-reactivity with recombinant human (rh) NALP1 (aa 1-323), rhNALP1 (aa 1331-1429), rhNALP2 (aa 1-208), rhNALP3 (aa 3-223), rhNALP3 (aa 540-689), rhNALP5 (aa 469-635), rhNOD1 (aa 830-953), or rhNOD2 (aa 230-450) is observed. Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP10 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It was initially identified as PYNOD, an Apaf-1-like protein that binds to ASC, caspase-1 and IL-1-b, inhibiting the autoprocessing of caspase-1, caspase-1-mediated IL-1-b processing, and ASC aggregation. NALP10 is thus a potent regulator of apoptosis and inflammation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NALP10
Applications Western Blot
Classification Monoclonal
Clone 578502
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene NLRP10
Gene Accession No. Q86W26, Q8CCN1
Gene Alias 6430548I20Rik; CLR11.1; NACHT, leucine rich repeat and PYD containing 10; NACHT, LRR and PYD containing protein 10; NACHT, LRR and PYD domains-containing protein 10; NACHT/LRR/pyrin domain-containing protein 10; NALP10; Napl10; neuronal apoptosis inhibitor protein 10; NLR family pyrin domain containing 10; NLR family, pyrin domain containing 10; NLRP10; NOD8; Nucleotide-binding oligomerization domain protein 8; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10; PAN5; Pynod
Gene Symbols NLRP10
Host Species Mouse
Immunogen E. coli-derived recombinant human NLRP10/Pynod/NALP10 Met386-Ile655.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 244202, 293426, 338322
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2b
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