Invitrogen™ NALP11 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA588368

Catalog No. PIPA588368

Description

Immunogen sequence: VGFTEADVSV LQAANILLPS NTHKDRYKFI HLNVQEFCTA IAFLMAVPNY LIPSGSREYK EKREQYSDFN QVFTFIFGLL NANRRKILET SFGYQLPMVD SFKWYSVGYM KHLDRDPEKL THHMPLFYCL YENREEEFVK TIVDALMEVT VYLQSDKDMM VSLYCLDYCC HLRTLKLSVQ R; Positive Samples: 293T.

NALP11 is a 1033 amino acid containing cytoplasmic protein belonging to the NLRP family with a DAPIN domain, six LRR (leucine-rich) repeats and a NACHT domain. Reports suggest that it is a short NALP involved in inflammation potential. NALP proteinsare implicated in the activation of proinflammatory caspases (e.g., CASP1) via their involvement in multiprotein complexes called inflammasomes. The DAPIN domain is necessary and sufficient for suppression of NF-kappa B activation induced by TNF and for inducing IL-1B secretion in collaboration with Caspase-1. It is involved in interaction with PYCARD.

Specifications

• Antigen: NALP11
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NLRP11
• Gene Alias: CLR19.6; NACHT, leucine rich repeat and PYD containing 11; NACHT, LRR and PYD domains-containing protein 11; NALP11; NLR family pyrin domain containing 11; NLR family, pyrin domain containing 11; NLRP11; NOD17; Nucleotide-binding oligomerization domain protein 17; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 11; PAAD- and NACHT-containing protein 10B; PAAD-and NACHT domain-containing protein 10; PAN10; PYPAF6; PYPAF7; PYRIN-containing APAF1-like protein 6
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 204801
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.26 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: P59045
• Gene Symbols: NLRP11
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 420-600 of human NLRP11 (NP_6594442).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG