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Invitrogen™ NALP12 Monoclonal Antibody (228CT4.1.3)
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Catalog No. PIMA537506
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400 μL
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Catalog No. Quantity
PIMA537506 400 μL
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Catalog No. PIMA537506 Supplier Invitrogen™ Supplier No. MA537506
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Description

Mouse Monoclonal Antibody

NALP12 Monoclonal Antibody for Western Blot

NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kappa-B activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NALP12
Applications Western Blot
Classification Monoclonal
Clone 228CT4.1.3
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene NLRP12
Gene Accession No. E9Q5R7
Gene Alias CLR19.3; FCAS2; monarch 1; monarch-1; NACHT, leucine rich repeat and PYD containing 12; NACHT, LRR and PYD containing protein 12; NACHT, LRR and PYD domains-containing protein 12; NALP12; NLR family pyrin domain containing 12; NLR family, pyrin domain containing 12; Nlrp12; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12; PAN6; PYPAF7; PYRIN-containing APAF1-like protein 7; regulated by nitric oxide; RNO; RNO2
Gene Symbols NLRP12
Host Species Mouse
Immunogen NLRP12 recombinant protein.
Purification Method Ammonium sulfate precipitation
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 378425
Target Species Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgM κ
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