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Invitrogen™ NALP12 Polyclonal Antibody
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Catalog No. PIPA560185
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PIPA560185 100 μL
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Catalog No. PIPA560185 Supplier Invitrogen™ Supplier No. PA560185
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LKRCRSAQVL HLYGATYSAD GEDRARCSAG AHTLLVQLPE RTVLLDAYSE HLAAALCTNP NLIELSLYRN ALGS Highest antigen sequence identity to the following orthologs: Mouse - 54%, Rat - 53%.

NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kappa-B activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NALP12
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene NLRP12
Gene Accession No. P59046
Gene Alias CLR19.3; FCAS2; monarch 1; monarch-1; NACHT, leucine rich repeat and PYD containing 12; NACHT, LRR and PYD containing protein 12; NACHT, LRR and PYD domains-containing protein 12; NALP12; NLR family pyrin domain containing 12; NLR family, pyrin domain containing 12; Nlrp12; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12; PAN6; PYPAF7; PYRIN-containing APAF1-like protein 7; regulated by nitric oxide; RNO; RNO2
Gene Symbols NLRP12
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human NALP12. Recombinant protein control fragment (Product #RP-99104).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 91662
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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