Invitrogen™ NALP12 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA572911

Catalog No. PIPA572911

Description

NALP12 Polyclonal Antibody for Western Blot, IHC (F), IHC (P), IP

NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kappa-B activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.

Specifications

• Antigen: NALP12
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NLRP12
• Gene Alias: CLR19.3; FCAS2; monarch 1; monarch-1; NACHT, leucine rich repeat and PYD containing 12; NACHT, LRR and PYD containing protein 12; NACHT, LRR and PYD domains-containing protein 12; NALP12; NLR family pyrin domain containing 12; NLR family, pyrin domain containing 12; Nlrp12; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12; PAN6; PYPAF7; PYRIN-containing APAF1-like protein 7; regulated by nitric oxide; RNO; RNO2
• Host Species: Rabbit
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Concentration: Conc. Not Determined
• Formulation: whole serum with 0.05% sodium azide
• Gene Accession No.: P59046
• Gene Symbols: NLRP12
• Immunogen: A synthetic peptide corresponding to amino acids 190-208 of human NALP12/PYPAF7/Monarch-1 was used as immunogen (NP_653288).
• Regulatory Status: RUO
• Gene ID (Entrez): 91662
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid