Invitrogen™ NALP12 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA589879

Catalog No. PIPA589879

Description

Positive Samples: Rat spleen; Cellular Location: Cytoplasm Immunogen sequence: WLKICRLTAA ACDELASTLS VNQSLRELDL SLNELGDLGV LLLCEGLRHP TCKLQTLRLG ICRLGSAACE GLSVVLQANH NLRELDLSFN DLGDWGLWLL AEGLQHPACR LQKLWLDSCG LTAKACENLY FTLGINQTLT DLYLTNNALG DTGVRLLCKR LSHPGCKLRV LWLFGMDLNK MTHSRLAALR VTKPYLDIGC.

NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kappa-B activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.

Specifications

• Antigen: NALP12
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NLRP12
• Gene Alias: CLR19.3; FCAS2; monarch 1; monarch-1; NACHT, leucine rich repeat and PYD containing 12; NACHT, LRR and PYD containing protein 12; NACHT, LRR and PYD domains-containing protein 12; NALP12; NLR family pyrin domain containing 12; NLR family, pyrin domain containing 12; Nlrp12; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12; PAN6; PYPAF7; PYRIN-containing APAF1-like protein 7; regulated by nitric oxide; RNO; RNO2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 292541, 91662
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.07 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: P59046
• Gene Symbols: NLRP12
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 862-1061 of human NLRP12 (NP_6532881).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov