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Invitrogen™ NALP2 Polyclonal Antibody
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Catalog No. PIPA529196
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100 μL
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PIPA529196 100 μL
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Catalog No. PIPA529196 Supplier Invitrogen™ Supplier No. PA529196
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: A431, H1299, HeLa, Molt-4. Predicted reactivity: Rhesus Monkey (82%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

NALP2 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli. Unlike the prototypical NALP protein NALP1, NALP2 only contains a NACHT domain, leucine rich repeat (LRR), and pyrin-containing domain (PYD). This protein interacts with the adapter protein ASC in addition to CARD8 and caspase-1 to form an inflammasome with high proIL-1-b-processing activity and is thought to function as a modulator of NF-kappa-B and procaspase-1 activation in macrophages. It has also been suggested that NALP2, in addition to other NALP family members, can act as innate sensors of pathogens in a manner similar to the toll-like receptors (TLRs). At least two alternatively spliced transcript variants encoding distinct isoforms have been found for NALP2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NALP2
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene NLRP2
Gene Accession No. Q9NX02
Gene Alias CLR19.9; E330007A02Rik; FLJ20510; LOC684545; NACHT, leucine rich repeat and PYD containing 2; NACHT, LRR and PYD containing protein 2; NACHT, LRR and PYD domains-containing protein 2; NALP2; NBS1; NLR family pyrin domain containing 2; NLR family, pyrin domain containing 2; NLRP2; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2; nucleotide-binding site protein 1; PAN1; PYPAF2; PYRIN domain and NACHT domain-containing protein 1; PYRIN-containing APAF1-like protein 2; similar to NACHT, leucine rich repeat and PYD containing 2
Gene Symbols NLRP2
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human NALP2. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55655
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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