Invitrogen™ NALP4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5139855

Catalog No. PIPA5139855

Description

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: FTLTKLSRDD IRSLCDALNY PAGNVKELAL VNCHLSPIDC EVLAGLLTNN KKLTYLNVSC NQLDTGVPLL CEALCSPDTV LVYLMLAFCH LS.

NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP4, also known as PYRIN-containing APAF1-like protein 4, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. In transfected 293 cells, NALP4 suppressed NF-kappa-B induction by TNF-a and IL-1-b, suggesting NALP4 operates at a point of convergence in these two signaling pathways. NALP4 also suppressed NF-kappa-B induction resulting from overexpression of several adapter proteins and protein kinases involved in these pathways, including TRAF2, TRAF6, RIP, and IRAK2, as well as the IKK-alpha and IKK-beta, suggesting that NALP4 is critical in modulating NF-kappa-B activity.

Specifications

• Antigen: NALP4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NLRP4
• Gene Alias: 4930406H16Rik; cancer/testis antigen 58; CLR19.5; CT58; E330021B02; E330028A19Rik; NACHT, leucine rich repeat and PYD containing 4; NACHT, leucine rich repeat and PYD containing 4A; NACHT, leucine rich repeat and PYD containing 4E; NACHT, LRR and PYD containing protein 4; NACHT, LRR and PYD domains-containing protein 4; NACHT, LRR and PYD domains-containing protein 4A; NACHT, LRR and PYD domains-containing protein 4E; NACHT/LRR/pyrin domain-containing protein 4; NALP, epsilon; NALP4; Nalp4a; Nalp4e; NALP-epsilon; Nalp-eta; Nalp-ita; NLR family pyrin domain containing 4; NLR family, pyrin domain containing 4; NLR family, pyrin domain containing 4A; NLR family, pyrin domain containing 4E; Nlrp4; Nlrp4a; Nlrp4e; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 4; PAAD and NACHT-containing protein 2; PAN2; PYPAF4; PYRIN and NACHT-containing protein 2; PYRIN-containing APAF1-like protein 4; RGD1561918; RGD1563529; Ribonuclease inhibitor 2; RNH2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 147945
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96MN2
• Gene Symbols: NLRP4
• Immunogen: Recombinant protein corresponding to Human NLRP4. Recombinant protein control fragment (Product #RP-109015).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG