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NALP4 Rabbit anti-Human, Polyclonal, Bioss
SDP

Rabbit Polyclonal Antibody

Supplier:  Bioss BS6855R

Encompass_Preferred

Catalog No. 50-198-7550


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Description

Description

NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP4, also known as PYRIN-containing APAF1-like protein 4, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. In transfected 293 cells, NALP4 suppressed NF-kappa-B induction by TNF-a and IL-1-b, suggesting NALP4 operates at a point of convergence in these two signaling pathways. NALP4 also suppressed NF-kappa-B induction resulting from overexpression of several adapter proteins and protein kinases involved in these pathways, including TRAF2, TRAF6, RIP, and IRAK2, as well as the IKK-alpha and IKK-beta, suggesting that NALP4 is critical in modulating NF-kappa-B activity.
Specifications

Specifications

NALP4
Polyclonal
Unconjugated
NLRP4
4930406H16Rik; Cancer/testis antigen 58; CLR19.5; CT58; E330021B02; E330028A19Rik; NACHT, leucine rich repeat and PYD containing 4; NACHT, leucine rich repeat and PYD containing 4A; NACHT, leucine rich repeat and PYD containing 4E; NACHT, LRR and PYD containing protein 4; NACHT, LRR and PYD domains-containing protein 4; NACHT, LRR and PYD domains-containing protein 4A; NACHT, LRR and PYD domains-containing protein 4E; NACHT/LRR/pyrin domain-containing protein 4; NALP, epsilon; NALP4; Nalp4a; Nalp4e; NALP-epsilon; Nalp-eta; NALP-ita; NLR family pyrin domain containing 4; NLR family, pyrin domain containing 4; NLR family, pyrin domain containing 4A; NLR family, pyrin domain containing 4E; Nlrp4; Nlrp4a; Nlrp4e; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 4; PAAD and NACHT-containing protein 2; PAN2; PYPAF4; PYRIN and NACHT-containing protein 2; PYRIN-containing APAF1-like protein 4; Ribonuclease inhibitor 2; RNH2
Rabbit
Protein A
RUO
147945
-20°C
Liquid
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 μg/mL
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Q96MN2
NLRP4
KLH conjugated synthetic peptide derived from human NALP4.
100 μL
Primary
Human
Antibody
IgG
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