Invitrogen™ NALP5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA563277

Catalog No. PIPA563277

Description

Immunogen sequence: LLPESFLIVT VRDVGTEKLK SEVVSPRYLL VRGISGEQRI HLLLERGIGE HQKTQGLRAI MNNRELLDQC QVPAVGSLIC VALQLQDVVG ESVAPFNQTL TGLHAAFVFH QLTPR Highest antigen sequence identity to the following orthologs: Mouse - 52%, Rat - 50%.

NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP5, also known as MATER, is a maternal gene required for early embryonic development in mice. Increased NALP5 expression was observed in two neuronal injury models, and transient expression of recombinant NALP5 in neurons induced caspase-3 activation and apoptosis, suggesting that NALP5 also plays a role in caspase activation and apoptosis in injured neurons, and may thus represent a novel target for therapeutic treatment in neurodegenerative disorders.

Specifications

• Antigen: NALP5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NLRP5
• Gene Alias: CLR19.8; MATER; Mater protein; Mater protein homolog; maternal antigen that embryos require; NACHT, leucine rich repeat and PYD containing 5; NACHT, LRR and PYD domains-containing protein 5; Nalp5; NLR family pyrin domain containing 5; NLR family, pyrin domain containing 5; NLRP5; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 5; Ooplasm-specific protein 1; OP1; PAN11; PYPAF8
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 126206
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P59047
• Gene Symbols: NLRP5
• Immunogen: Recombinant protein corresponding to Human NALP5.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG