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Invitrogen™ NANOS3 Polyclonal Antibody
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Catalog No. PIPA5115615
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100 μL
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PIPA5115615 100 μL
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Catalog No. PIPA5115615 Supplier Invitrogen™ Supplier No. PA5115615
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total Nanos3.

Nanos is a zinc-finger containing, RNA-binding protein that has been implicated in germ cell development in both invertebrates and vertebrates. In Drosophila, Nanos represses apoptosis during development to ensure proper germ-line development. Unlike Nanos1 whose expression in mice is dispensable, the Nanos2 and Nanos3 proteins are required for germ cell development. Nanos2-null primordial germ cells (PGCs) die only in the male gonads and show no defects in females, while Nanos3-null PGCs are lost during the migration stage regardless of sex. Nanos2 and Nanos3 have distinct expression patterns during embryo development, suggesting that these two proteins do not have redundant functions. However, expression of Nanos2 can at least partially replace Nanos3 function in a Nanos3-null background. Nanos3 expression can not rescue Nanos2-null defects.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NANOS3
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene NANOS3
Gene Accession No. P60323, P60324
Gene Alias nanos C2HC-type zinc finger 3; nanos homolog 3; nanos homolog 3 (Drosophila); NANOS1L; NANOS3; NOS3; NOS-3; ZC2HC12C
Gene Symbols NANOS3
Host Species Rabbit
Immunogen A synthesized peptide derived from human NANOS3(Accession P60323), corresponding to amino acid residues Q114-S164.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 244551, 342977
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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