Nanos3 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-0759	100 μL

Catalog No. 50-198-0759 Supplier Bioss Supplier No. BS10227R

Description

Rabbit Polyclonal Antibody

Nanos is a zinc-finger containing, RNA-binding protein that has been implicated in germ cell development in both invertebrates and vertebrates. In Drosophila, Nanos represses apoptosis during development to ensure proper germ-line development. Unlike Nanos1 whose expression in mice is dispensable, the Nanos2 and Nanos3 proteins are required for germ cell development. Nanos2-null primordial germ cells (PGCs) die only in the male gonads and show no defects in females, while Nanos3-null PGCs are lost during the migration stage regardless of sex. Nanos2 and Nanos3 have distinct expression patterns during embryo development, suggesting that these two proteins do not have redundant functions. However, expression of Nanos2 can at least partially replace Nanos3 function in a Nanos3-null background. Nanos3 expression can not rescue Nanos2-null defects.

Specifications

• Antigen: Nanos3
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: NANOS3
• Gene Accession No.: P60323
• Gene Alias: nanos C2HC-type zinc finger 3; Nanos homolog 3; nanos homolog 3 (Drosophila); NANOS1L; Nanos3; NOS3; NOS-3; ZC2HC12C
• Gene Symbols: NANOS3
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human Nanos3.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 342977
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG