Invitrogen™ NARF Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA565754

Catalog No. PIPA565754

Description

Immunogen sequence: KTDDQENVSAD APSPAQENGE KGEFHKLADA KIFLSDCLAC DSCMTAEEGV QLSQQNAKDF FRVLNLNKKC DTSKHKVLVV SVCPQSLPYF AAKFNLSVTD ASRRLCGFLK SLG Highest antigen sequence identity to the following orthologs - mouse 84%, rat 93%.

Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing.

Specifications

• Antigen: NARF
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NARF
• Gene Alias: 4430402O11Rik; IOP2; iron-only hydrogenase-like protein 2; Narf; Nuclear prelamin A recognition factor; prenyl-dependent prelamin A binding protein; RGD1310894
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26502
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9UHQ1
• Gene Symbols: NARF
• Immunogen: Recombinant Human NARF. Recombinant protein control fragment (Product #RP-104958).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov