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Invitrogen™ NARF Polyclonal Antibody
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Catalog No. PIPA565754
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PIPA565754 100 μL
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Catalog No. PIPA565754 Supplier Invitrogen™ Supplier No. PA565754
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KTDDQENVSAD APSPAQENGE KGEFHKLADA KIFLSDCLAC DSCMTAEEGV QLSQQNAKDF FRVLNLNKKC DTSKHKVLVV SVCPQSLPYF AAKFNLSVTD ASRRLCGFLK SLG Highest antigen sequence identity to the following orthologs - mouse 84%, rat 93%.

Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NARF
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene NARF
Gene Accession No. Q9UHQ1
Gene Alias 4430402O11Rik; IOP2; iron-only hydrogenase-like protein 2; Narf; Nuclear prelamin A recognition factor; prenyl-dependent prelamin A binding protein; RGD1310894
Gene Symbols NARF
Host Species Rabbit
Immunogen Recombinant Human NARF. Recombinant protein control fragment (Product #RP-104958).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26502
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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