NARF Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-1141	100 μL

Catalog No. 50-198-1141 Supplier Bioss Supplier No. BS11173R

Description

Rabbit Polyclonal Antibody

Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing.

Specifications

• Antigen: NARF
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: NARF
• Gene Accession No.: Q9UHQ1
• Gene Alias: 4430402O11Rik; IOP2; Iron-only hydrogenase-like protein 2; Narf; Nuclear prelamin A recognition factor; prenyl-dependent prelamin A binding protein; RGD1310894
• Gene Symbols: NARF
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human NARF.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 26502
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG