NAT1 Mouse anti-Human, Clone: OTI7G6, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF810662

Catalog No. 50-167-0235

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Arylamine N-acetyltransferases (NAT-1 and NAT-2) catalyze N- or O-acetylation of heterocyclic and arylamine substrates in the detoxification of a wide array of drugs. Certain alleles causing high N-acetyltransferase activity have been associated with colon and urinary bladder cancers, as NATs also bioactivate several known carcinogens. Both NAT-1 and NAT-2 are cytoplasmic proteins and play an active role in the detoxification of many arylamine and hydrazine drugs. N-acetylation polymorphism is determined by the level of NAT activity in liver tissues, and has been linked to the action and toxicity of drugs that contain amines. Human NAT-1 is the functional homolog of rodent NAT-2, while human NAT-2 is the functional homolog of rodent NAT-1.

Specifications

• Antigen: NAT1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: NAT1
• Gene Alias: AAC1, MNAT, NAT-1, NATI
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI7G6
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P18440
• Gene Symbols: NAT1
• Immunogen: Full length human recombit protein of human NAT1 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1