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Invitrogen™ NAT1 Polyclonal Antibody
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Catalog No. PIPA560474
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100 μL
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PIPA560474 100 μL
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Catalog No. PIPA560474 Supplier Invitrogen™ Supplier No. PA560474
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SRNKLDLETL TDILQHQIRA VPFENLN Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 89%.

Arylamine N-acetyltransferases (NAT-1 and NAT-2) catalyze N- or O-acetylation of heterocyclic and arylamine substrates in the detoxification of a wide array of drugs. Certain alleles causing high N-acetyltransferase activity have been associated with colon and urinary bladder cancers, as NATs also bioactivate several known carcinogens. Both NAT-1 and NAT-2 are cytoplasmic proteins and play an active role in the detoxification of many arylamine and hydrazine drugs. N-acetylation polymorphism is determined by the level of NAT activity in liver tissues, and has been linked to the action and toxicity of drugs that contain amines. Human NAT-1 is the functional homolog of rodent NAT-2, while human NAT-2 is the functional homolog of rodent NAT-1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NAT1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.7 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene NAT1
Gene Accession No. P18440
Gene Alias AAC1; Arylamide acetylase 1; arylamine N-acetyltransferase 1; AT-1; MNAT; Monomorphic arylamine N-acetyltransferase; N(alpha)-acetyltransferase 15, NatA auxiliary subunit; N-acetyl transferase 1; N-acetyl transferase 1, liver, blood; N-acetyltransferase (arylamine N-acetyltransferase); N-acetyltransferase 1; N-acetyltransferase 1 (arylamine N-acetyltransferase); N-acetyltransferase type 1; Nat; Nat1; NAT-1; NATI
Gene Symbols NAT1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human NAT1. Recombinant protein control fragment (Product #RP-99582).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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