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Invitrogen™ Natalizumab Chimeric Recombinant Rabbit Monoclonal Antibody (Natalizumab)
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Catalog No. PIMA548046
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200 μg
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Catalog No. Quantity
PIMA548046 200 μg
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Catalog No. PIMA548046 Supplier Invitrogen™ Supplier No. MA548046
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: This antibody binds to the alpha 4 binds subunit of alpha-4Beta1 (also known as very late antigen 4 [VLA-4] or CD49d-CD29) and alpha-4Beta7 integrin.

Natalizumab is a recombinant, humanized monoclonal antibody, binds to alpha4beta1-integrinand blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). Natalizumab can be used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease. Natalizumab is also the first targeted therapy which blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Natalizumab Chimeric
Applications Flow Cytometry, Inhibition Assays
Classification Recombinant Monoclonal
Clone Natalizumab
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene Alias AN 100226; BG00002
Host Species Rabbit
Immunogen The RAMOS cell line, a non-EBV releasing cell line, injected into mice.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG κ
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